Formulation and Evaluation of Sustained Release Verapamil Hydrochloride Using Natural Polymers

Article English OPEN
Kumar, S. Ullas ; Ramu, B. ; Srikanth, G. ; Rajkamal, Dr. Bigala (2016)
  • Publisher: Sierra Journals Publisher
  • Journal: International Journal of Applied Pharmaceutical Sciences and Research (issn: 2455-8095, eissn: 2455-8095)
  • Related identifiers: doi: 10.21477/ijapsr.v1i2.10179
  • Subject: verapamil hydrochloride; natural polymer; sustained release; formulation; evaluation. | Pharmaceutical Sciences; Pharmaceutics

The aim of the present study was to develop sustained release formulation of Verapamil Hydrochloride to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of HPMC polymers, Guar gum, and Xanthum gum were employed as polymers. Verapamil Hydrochloride dose was fixed as 120 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the concentration of 60, 120 and 180 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,96.10 % in 12 hours containing Guar gum polymer in the concentration of 180mg. It followed zero order release kinetics. For the optimized formulation alcohol effect has been studied by using various concentrations of alcohol in dissolution medium. As the concentration of alcohol increased the sustained action of polymer was decreased. Hence it was concluded that alcohol has significant effect on drug release pattern.
  • References (21)
    21 references, page 1 of 3

    Airaj Mahajabeen, Dr. E. Hari Krishna, Ramya Sri Sura (2015). Formulation and evaluation of leveriracetam extended release tablets. World Journal of Pharmacy and Pharmaceutical Sciences. 4(4):1446-1460.

    Jadhav (2011). Formulation and evaluation of citicoline sustained release tablet. J. Pharm. Sci & Res. 3(1): 911-917.

    Ashwini Rajendra, Bushetti SS (2012).

    Formulation and evaluation of matrix tablets based on polyelectrolyte complex between okra mucilage and chitosan. International Research Journal of Pharmacy. 3(2):279-286.

    Bala R, Pawar P, Khanna S, et al (2013).

    3(2):67-76.http://doi.org/10.4103/2230- 973X.114897 Bandameedi R, Pandiyan S (2015).

    7:209. doi: 10.4172/1920- 4159.1000209.

    Chintanippula Sai Rama Rao, Sharath K, Kowmudi V, Suresh N (2016). Development and In-vitro Evaluation of Cefpodoxime Proxetil Gastro-Retentive Floating Tablets. Int J App Pharm Sci Res. 1(1):31-41.

    D. Pavani, E. Hari Krishna, Ramesh S (2015).

    Hareesh Dara, Narasimha Reddy Yellu (2015).

  • Metrics
    No metrics available
Share - Bookmark