Multinucleotide mutations cause false inferences of positive selection

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Thornton, Joseph; Venkat, Aarti; Hahn, Matthew;
(2017)

Phylogenetic tests of adaptive evolution, which infer positive selection from an excess of nonsynonymous changes, assume that nucleotide substitutions occur singly and independently. But recent research has shown that multiple errors at adjacent sites often occur in sin... View more
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