Progressive impairment of directional and spatially precise trajectories by TgF344-AD Rats in the Morris Water Task

Preprint OPEN
Thompson, Shannon; Harvey, Ryan; Clark, Benjamin; Drake, Emma; Berkowitz, Laura;
(2018)

Spatial navigation is impaired in early stages of Alzheimers disease (AD), and may be a defining behavioral marker of preclinical AD. Nevertheless, limitations of diagnostic criteria for AD and within animal models of AD make characterization of preclinical AD difficult... View more
  • References (59)
    59 references, page 1 of 6

    Aggleton, J.P., Pralus, A., Nelson, A.J.D., Hornberger, M., 2016. Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit. Brain 139, 1877-1890. https://doi.org/10.1093/brain/aww083

    Association, A., others, 2017. 2017 Alzheimer's disease facts and figures. Alzheimers Dement. 13, 325-373.

    Bianchini, F., Di Vita, A., Palermo, L., Piccardi, L., Blundo, C., Guariglia, C., 2014. A Selective Egocentric Topographical Working Memory Deficit in the Early Stages of Alzheimer's Disease: A Preliminary Study. Am. J. Alzheimers Dis. Dementiasr 29, 749-754. https://doi.org/10.1177/1533317514536597

    Bird, C.M., Chan, D., Hartley, T., Pijnenburg, Y.A., Rossor, M.N., Burgess, N., 2010. Topographical short-term memory differentiates Alzheimer's disease from frontotemporal lobar degeneration. Hippocampus 20, 1154-1169. https://doi.org/10.1002/hipo.20715

    Braak, H., Braak, E., 1995. Staging of alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging, The Schmitt Symposium: The Cytoskeleton and Alzheimer's Disease 16, 271-278. https://doi.org/10.1016/0197-4580(95)00021-6

    Brody, D.L., Holtzman, D.M., 2006. Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Exp. Neurol. 197, 330-340. https://doi.org/10.1016/j.expneurol.2005.10.020

    Chan, D., Gallaher, L.M., Moodley, K., Minati, L., Burgess, N., Hartley, T., 2016. The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease. J. Vis. Exp. JoVE. https://doi.org/10.3791/54454

    Clark, B., Rice, J.P., Akers, K.G., Candelaria-Cook, F.T., Taube, J.S., Hamilton, D.A., 2013. Lesions of the dorsal tegmental nuclei disrupt control of navigation by distal landmarks in cued, directional, and place variants of the Morris water task. Behav. Neurosci. 127, 566-581. https://doi.org/10.1037/a0033087

    Clark, B.J., Harvey, R.E., 2016. Do the anterior and lateral thalamic nuclei make distinct contributions to spatial representation and memory? Neurobiol. Learn. Mem. 133, 69-78. https://doi.org/10.1016/j.nlm.2016.06.002

    Clark, B.J., Hong, N.S., Bettenson, D.J., Woolford, J., Horwood, L., McDonald, R.J., 2015. Maintained directional navigation across environments in the Morris water task is dependent on vestibular cues. J. Exp. Psychol. Anim. Learn. Cogn. 41, 301-308. https://doi.org/10.1037/xan0000066

  • Related Organizations (2)
  • Metrics
Share - Bookmark