Nanoscale mechanical stimulation method for quantifying C. elegans mechanosensory behavior and memory

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Kiso, Kaori ; Sugi, Takuma ; Okumura, Etsuko ; Igarashi, Ryuji (2016)
  • Related identifiers: doi: 10.1101/047431
  • Subject: bepress|Life Sciences|Biology | bepress|Life Sciences|Genetics and Genomics|Genetics

Here, we establish a novel economic system to quantify C. elegans mechanosensory behavior and memory by a controllable nanoscale mechanical stimulation. Using piezoelectric sheet speaker, we can flexibly change the vibration properties at a nanoscale displacement level and quantify behavioral responses and memory under the control of each vibration property. This system will facilitate understanding of physiological aspects of C. elegans mechanosensory behavior and memory.
  • References (2)

    1. Hoffman, B. D., Grashoff, C. & Schwartz, M. A. Dynamic molecular processes mediate cellular mechanotransduction. Nature 475, 316-323 (2011).

    2. Delmas, P., Hao, J. & Rodat-Despoix, L. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci 12, 139-153 (2011).

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