Bamgineer: Introduction of simulated allele-specific copy number variants into exome and targeted sequence data sets.

Article, Preprint English OPEN
Samadian, Soroush; Bruce, Jeff P.; Pugh, Trevor J.;
(2018)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Computational Biology,volume 14,issue 3 (issn: 1553-734X, eissn: 1553-7358)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5891060, doi: 10.1371/journal.pcbi.1006080, doi: 10.1101/119636
  • Subject: Computational Biology | Molecular biology | Research Article | Sequence Alignment | DNA sequence analysis | Genome Complexity | Genetic Loci | Genetics | Copy Number Variation | Genome Analysis | Molecular biology techniques | Genomics | Sequence analysis | Database and informatics methods | Alleles | Molecular Genetics | DNA sequencing | Sequencing techniques | Biology and life sciences | bepress|Life Sciences|Bioinformatics | Research and analysis methods | Heredity | QH301-705.5 | bepress|Life Sciences|Biology | Haplotypes | Genetic Mapping | Bioinformatics | Biology (General)

Somatic copy number variations (CNVs) play a crucial role in development of many human cancers. The broad availability of next-generation sequencing data has enabled the development of algorithms to computationally infer CNV profiles from a variety of data types includi... View more
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