Systematic integration of biomedical knowledge prioritizes drugs for repurposing

Preprint OPEN
Hadley, Dexter; Chen, Sabrina; Brueggeman, Leo; Hessler, Christine; Lizee, Antoine; Himmelstein, Daniel; Baranzini, Sergio; Chen, Sabrina; Baranzini, Sergio; Khankhanian, Pouya; Green, Ari;
(2017)
  • Related identifiers: doi: 10.1101/087619
  • Subject: bepress|Life Sciences|Biology | bepress|Life Sciences|Bioinformatics

The ability to computationally predict whether a compound treats a disease would improve the economy and success rate of drug approval. This study describes Project Rephetio to systematically model drug efficacy based on 755 existing treatments. First, we constructed He... View more
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