Synaptic transmission modulates while non-synaptic processes govern the transition from pre-ictal to seizure activity in vitro

Preprint OPEN
Jefferys, John; Fox, John; Jiruska, Premysl; Kronberg, Greg; Miranda, Dolores; Ruiz-Nuño, Ana; Bikson, Marom;
(2018)
  • Related identifiers: doi: 10.1101/280321
  • Subject:
    mesheuropmc: nervous system diseases | nervous system

It is well established that non-synaptic mechanisms can generate electrographic seizures after blockade of synaptic function. We investigated the interaction of intact synaptic activity with non-synaptic mechanisms in the isolated CA1 region of rat hippocampal slices us... View more
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