Ancestral diet leads to dynamic transgenerational plasticity for five generations in Drosophila melanogaster

Preprint OPEN
Mikheyev, Alexander; Emborski, Carmen;
(2018)

Ancestral exposures can influence phenotypic expression in subsequent generations, which influence diverse biological processes ranging from phenotypic plasticity to obesity. Currently, most transgenerational studies work under the assumption of transgenerational respon... View more
  • References (46)
    46 references, page 1 of 5

    Aerts, L. & Van Assche, F. A. 2006. Animal evidence for the transgenerational development of diabetes mellitus. Int J Biochem Cell Biol, 38, 894-903.

    Armitage, J. A., Ishibashi, A., Balachandran, A. A., Jensen, R. I., Poston, L. & Taylor, P. D. 2007. Programmed aortic dysfunction and reduced Na+,K+-ATPase activity present in first generation offspring of lard-fed rats does not persist to the second generation. Experimental Physiology, 92, 583-589.

    Ashe, A., Sapetschnig, A., Weick, E. M., Mitchell, J., Bagijn, M. P., Cording, A. C., Doebley, A. L., Goldstein, L. D., Lehrbach, N. J., Le Pen, J., Pintacuda, G., Sakaguchi, A., Sarkies, P., Ahmed, S. & Miska, E. A. 2012. piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans. Cell, 150, 88- 99.

    Ayyanath, M.-M., Cutler, G. C., Scott-Dupree, C. D. & Sibley, P. K. 2013. Transgenerational shifts in reproduction hormesis in green peach aphid exposed to low concentrations of imidacloprid. PLoS One, 8, e74532.

    Benjamini, Y. & Hochberg, Y. 1995. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society. Series B (Methodological), 57, 289-300.

    Benyshek, D. C., Johnston, C. S. & Martin, J. F. 2006. Glucose metabolism is altered in the adequately-nourished grand-offspring (F3 generation) of rats malnourished during gestation and perinatal life. Diabetologia, 49, 1117-9.

    Bonduriansky, R. 2012. Rethinking heredity, again. Trends Ecol Evol, 27, 330-6.

    Bonduriansky, R. & Day, T. 2009. Nongenetic Inheritance and Its Evolutionary Implications. Annual Review of Ecology, Evolution, and Systematics, 40, 103-125.

    Buescher, J. L., Musselman, L. P., Wilson, C. A., Lang, T., Keleher, M., Baranski, T. J. & Duncan, J. G. 2013. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech, 6, 1123-32.

    Burks, D. J., De Mora, J. F., Schubert, M., Withers, D. J., Myers, M. G., Towery, H. H., Altamuro, S. L., Flint, C. L. & White, M. F. 2000. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature, 407, 377-382.

  • Related Organizations (10)
  • Metrics
Share - Bookmark

  • Download from
    bioRxiv via bioRxiv (Preprint, 2018)
  • Cite this publication