An open library of human kinase domain constructs for automated bacterial expression

Preprint OPEN
Rodríguez-Laureano, Lucelenie; Işık, Mehtap; Chodera, John; Seeliger, Markus; Jeans, Chris; Gradia, Scott; Hanson, Sonya; Parton, Daniel; Albanese, Steven; Levinson, Nicholas; Behr, Julie;
(2017)
  • Related identifiers: doi: 10.1101/038711
  • Subject: bepress|Life Sciences|Biology | bepress|Life Sciences|Biochemistry, Biophysics, and Structural Biology|Biochemistry

Kinases play a critical role in many cellular signaling pathways and are dysregulated in a number of diseases, such as cancer, diabetes, and neurodegeneration. Since the FDA approval of imatinib in 2001, therapeutics targeting kinases now account for roughly 50% of curr... View more
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