MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

Preprint OPEN
Haycock, Philip; Gaunt, Tom; Smith, George; Martin, Richard; Relton, Caroline; Evans, David; Timpson, Nicholas; Shihab, Hashem; Yarmolinsky, James; Laurin, Charles; Zheng, Jie; Elsworth, Benjamin; Wade, Kaitlin; Hemani, Gibran; Burgess, Stephen; Bowden, Jack; Langdon, Ryan; Tan, Vanessa; Collaboration, The Mr-Base;
  • Related identifiers: doi: 10.1101/078972
  • Subject: bepress|Life Sciences|Biology | bepress|Medicine and Health Sciences|Public Health|Epidemiology

Published genetic associations can be used to infer causal relationships between phenotypes, bypassing the need for individual-level genotype or phenotype data. We have curated complete summary data from 1094 genome-wide association studies (GWAS) on diseases and other ... View more
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