publication . Preprint . Other literature type . 2018

AutonoMouse: High throughput automated operant conditioning shows progressive behavioural impairment with graded olfactory bulb lesions

Andrew Erskine; Thorsten Bus; Andreas T. Schaefer; Jan T Herb;
Open Access English
  • Published: 29 Mar 2018
  • Publisher: Cold Spring Harbor Laboratory
Abstract
<jats:title>Abstract</jats:title><jats:p>Operant conditioning is a crucial tool in neuroscience research for probing brain function. While molecular, anatomical and even physiological techniques have seen radical increases in throughput, efficiency, and reproducibility in recent years, behavioural tools have seen much less of an improvement. Here we present a fully automated, high-throughput system for self-initiated conditioning of up to 25 group-housed, radio-frequency identification (RFID) tagged mice over periods of several months and &gt;10^6 trials. We validate this “AutonoMouse” system in a series of olfactory behavioural tasks and show that acquired data...
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doi: 10.1101/291815
Subjects
free text keywords: Olfactory behaviour, Neuroscience research, Computer science, Throughput, Conditioning, Neuroscience, Operant conditioning, Olfactory bulb, Fully automated, Brain function
Related Organizations
Funded by
WT| Behavioural role and neural representation of temporal dynamics in sensory stimuli.
Project
Behavioural role and neural representation of temporal dynamics in sensory stimuli.
  • Funder: Wellcome Trust (WT)
  • Project Code: 110174
  • Funding stream: Cellular and Molecular Neuroscience
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Abraham, N. M. et al. (2004) 'Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice.', Neuron. Elsevier, 44(5), pp. 865-876.

Abraham, N. M. et al. (2010) 'Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice.', Neuron. Elsevier Ltd, 65(3), pp. 399-411.

Abraham, N. M. et al. (2012) 'Similar odor discrimination behavior in head-restrained and freely moving mice.', PloS one. United States, 7(12), p. e51789.

Aoki, R. et al. (2017) 'An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation', Nature Communications. Springer US, 8(1).

Aronov, D., Nevers, R. and Tank, D. W. (2017) 'Mapping of a non-spatial dimension by the hippocampal-entorhinal circuit', Nature. Nature Publishing Group, 543(7647), pp. 719-722. [OpenAIRE]

Ben Arous, J. et al. (2010) 'Automated imaging of neuronal activity in freely behaving Caenorhabditis elegans', Journal of Neuroscience Methods. Elsevier B.V., 187(2), pp. 229-234.

Francis, N. A. and Kanold, P. O. (2017) 'Automated Operant Conditioning in the Mouse Home Cage', Frontiers in Neural Circuits, 11(March), pp. 1-6.

Meaney, M. J. et al. (1996) 'Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress.', Developmental Neuroscience, 18(1- 2), pp. 61-72. [OpenAIRE]

Wilson, R. I. and Mainen, Z. F. (2006) 'Early events in olfactory processing.', Annual review of neuroscience, 29, pp. 163-201. [OpenAIRE]

Related research
Abstract
<jats:title>Abstract</jats:title><jats:p>Operant conditioning is a crucial tool in neuroscience research for probing brain function. While molecular, anatomical and even physiological techniques have seen radical increases in throughput, efficiency, and reproducibility in recent years, behavioural tools have seen much less of an improvement. Here we present a fully automated, high-throughput system for self-initiated conditioning of up to 25 group-housed, radio-frequency identification (RFID) tagged mice over periods of several months and &gt;10^6 trials. We validate this “AutonoMouse” system in a series of olfactory behavioural tasks and show that acquired data...
Read more
doi: 10.1101/291815
Subjects
free text keywords: Olfactory behaviour, Neuroscience research, Computer science, Throughput, Conditioning, Neuroscience, Operant conditioning, Olfactory bulb, Fully automated, Brain function
Related Organizations
Funded by
WT| Behavioural role and neural representation of temporal dynamics in sensory stimuli.
Project
Behavioural role and neural representation of temporal dynamics in sensory stimuli.
  • Funder: Wellcome Trust (WT)
  • Project Code: 110174
  • Funding stream: Cellular and Molecular Neuroscience
Download fromView all 3 versions
bioRxiv
Preprint . 2018
Provider: bioRxiv
https://www.biorxiv.org/conten...
Preprint
Provider: UnpayWall
http://dx.doi.org/10.1101/2918...
Other literature type . 2018
Provider: Datacite
https://www.biorxiv.org/conten...
Preprint
Provider: Microsoft Academic Graph
View more

Abraham, N. M. et al. (2004) 'Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice.', Neuron. Elsevier, 44(5), pp. 865-876.

Abraham, N. M. et al. (2010) 'Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice.', Neuron. Elsevier Ltd, 65(3), pp. 399-411.

Abraham, N. M. et al. (2012) 'Similar odor discrimination behavior in head-restrained and freely moving mice.', PloS one. United States, 7(12), p. e51789.

Aoki, R. et al. (2017) 'An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation', Nature Communications. Springer US, 8(1).

Aronov, D., Nevers, R. and Tank, D. W. (2017) 'Mapping of a non-spatial dimension by the hippocampal-entorhinal circuit', Nature. Nature Publishing Group, 543(7647), pp. 719-722. [OpenAIRE]

Ben Arous, J. et al. (2010) 'Automated imaging of neuronal activity in freely behaving Caenorhabditis elegans', Journal of Neuroscience Methods. Elsevier B.V., 187(2), pp. 229-234.

Francis, N. A. and Kanold, P. O. (2017) 'Automated Operant Conditioning in the Mouse Home Cage', Frontiers in Neural Circuits, 11(March), pp. 1-6.

Meaney, M. J. et al. (1996) 'Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress.', Developmental Neuroscience, 18(1- 2), pp. 61-72. [OpenAIRE]

Wilson, R. I. and Mainen, Z. F. (2006) 'Early events in olfactory processing.', Annual review of neuroscience, 29, pp. 163-201. [OpenAIRE]

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