Single-cell RNA sequencing reveals cell-type specific cis-eQTLs in peripheral blood mononuclear cells

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Van Der Wijst, Monique; Franke, Lude; De Vries, Dylan; Brugge, Harm;
(2017)

Most disease-associated genetic risk factors are regulatory. Here, we generated single-cell RNA-seq data of ~25,000 peripheral blood mononuclear cells from 45 donors to identify how genetic variants affect gene expression. We validated this approach by replicating previ... View more
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