Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

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Tiger Li, Zheng-Rong; Zarnitsyna, Veronika I.; Lowen, Anice C.; Weissman, Daniel; Koelle, Katia; Kohlmeier, Jacob E.; Antia, Rustom;

Abstract The high-degree conservation of CD8 T cell epitopes of influenza A virus (IAV) may allow T cell-inducing vaccines effective across different strains and subtypes. This conservation is not fully explained by functional constraint, since additional mutation(s) c... View more
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