publication . Other literature type . Article . Preprint . 2018 . Embargo end date: 01 Jan 2018

Reproducibility and replicability of rodent phenotyping in preclinical studies.

Neri Kafkafi; Joseph Agassi; Elissa J. Chesler; John C. Crabbe; Wim E. Crusio; David Eilam; Robert Gerlai; Ilan Golani; Alex Gomez-Marin; Ruth Heller; ...
Open Access English
  • Published: 01 Apr 2018
  • Publisher: Elsevier
Abstract
AbstractThe scientific community is increasingly concerned with cases of published “discoveries” that are not replicated in further studies. The field of mouse behavioral phenotyping was one of the first to raise this concern, and to relate it to other complicated methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of the mouse as a model animal for human health and disease mechanisms. In January 2015, researchers from various disciplines including genetics, behavior genetics, neuroscience, ethology, statistics and bioinformatics gathered in Tel Aviv University to discuss these is...
Subjects
free text keywords: 630 Agriculture, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Data sharing, False discoveries, GxE interaction, Heterogenization, Replicability, Reproducibility, Validity, Neuropsychology and Physiological Psychology, Cognitive Neuroscience, Behavioral Neuroscience, Animals, Rodentia, Animal Experimentation, Reproducibility of Results, Models, Animal, Behavior, Information Dissemination, Phenotype, Research, Research Design, Data sharing, False discoveries, GxE interaction, Heterogenization, Replicability, Reproducibility, Validity, Medical and Health Sciences, Psychology and Cognitive Sciences, Behavioral Science & Comparative Psychology, Article, Data science, Disease mechanisms, Metadata, Generalizability theory, Behavioural genetics, Bioinformatics, Human health, Ethology, Tel aviv, Psychology, Data sharing
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