publication . Other literature type . Preprint . Article . 2017

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Faisal Raza; Hajra Zafar; Ying Zhu; Yuan Ren; Aftab -Ullah; Asif Ullah Khan; Xinyi He; Han Han; Md Aquib; Kofi Oti Boakye-Yiadom; ...
Open Access
  • Published: 30 Oct 2017
  • Publisher: MDPI AG
Abstract
Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to overcome the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. The aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. Peptide a...
Subjects
Medical Subject Headings: technology, industry, and agriculturemacromolecular substancescomplex mixtures
free text keywords: nanotechnology, Pharmaceutical Science, Review, hydrogels, peptides, proteins, crosslinked networks, controlled release, biodegradable polymers, Pharmacy and materia medica, RS1-441
187 references, page 1 of 13

1. Martinho, N., C. Damgé, and C.P. Reis, Recent advances in drug delivery systems. Journal of biomaterials and nanobiotechnology, 2011. 2(05): p. 510.

2. Graham, N., Hydrogels in controlled drug delivery, in Polymeric Biomaterials. 1986, Springer. p. 170-194.

3. Bajpai, S. and J. Sonkusley, Hydrogels for oral drug delivery of peptides: Synthesis and characterization. Journal of applied polymer science, 2002. 83(8): p. 1717-1729. [OpenAIRE]

4. Nguyen, Q.V., J.H. Park, and D.S. Lee, Injectable polymeric hydrogels for the delivery of therapeutic agents: A review. European Polymer Journal, 2015. 72: p. 602-619.

5. Buchholz, F.L. and A.T. Graham, Modern superabsorbent polymer technology. John! Wiley & Sons, Inc, 605 Third Ave, New York, NY 10016, USA, 1998. 279, 1998.

6. Brannon-Peppas, L. and R.S. Harland, Absorbent polymer technology. Vol. 8. 2012: Elsevier.

7. Li, Y., et al., Magnetic hydrogels and their potential biomedical applications. Advanced Functional Materials, 2013. 23(6): p. 660-672.

8. Wichterle, O. and D. Lim, Hydrophilic gels for biological use. Nature, 1960. 185(4706): p. 117-118. [OpenAIRE]

9. Iizawa, T., et al., Synthesis of porous poly (N-isopropylacrylamide) gel beads by sedimentation polymerization and their morphology. Journal of applied polymer science, 2007. 104(2): p. 842-850. [OpenAIRE]

10. Rosiak, J.M. and F. Yoshii, Hydrogels and their medical applications. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1999. 151(1): p. 56-64. [OpenAIRE]

11. EL-HAFIAN, E.A., et al., Characterization of chitosan in acetic acid: Rheological and thermal studies. Turkish Journal of Chemistry, 2010. 34(1): p. 47-56.

12. Khan, A., et al., Synthesis and physicochemical investigation of chitosan-PMAA-based dual-responsive hydrogels. Journal of Polymer Research, 2013. 20(10): p. 273.

13. Ahmed, E.M., Hydrogel: Preparation, characterization, and applications: A review. Journal of advanced research, 2015. 6(2): p. 105-121. [OpenAIRE]

14. Roorda, W., et al., Synthetic hydrogels as drug delivery systems. Pharmaceutisch Weekblad, 1986. 8(3): p. 165-189.

15. Park, H., K. Park, and W.S. Shalaby, Biodegradable hydrogels for drug delivery. 2011: CRC Press.

187 references, page 1 of 13
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