Aim of research. To detect the features of histopathological changes of gastric mucosa (GM) in patients with chronic gastritis (CG) associated with osteoarthritis (OA) under conditions of NAP-therapy.Materials and methods of research. The complex examination was carried out in 507 patients, 40 - 65 (52,5±4,32) years old, including 310 women and 197 men. All patients were divided in 2 clinical groups: 1 group included 357 patients with OA, associated with CG, 2 group ‒ 150 patients with CG without joint pathology. Then the patients with CG of both groups were divided depending on the presence of atrophy and its stage: non-atrophic gastritis (NAG) took place in 117 and 51 patients from І and ІІ groups, respectively; initial atrophy (IA) that corresponds to the I and II stage of atrophy, according to OLGA system, was detected in 128 and 54 patients from І and ІІ groups, respectively; the heavy atrophy (HA) that corresponds to ІІІ and ІV stage of atrophy, according to OLGA system, was fixed in 112 and 45 patients from І and ІІ groups, respectively.Нp-infection was detected using two methods: fast urease test and cystoscopy of smears of imprints, colored according to Romanovsky-Gimza. The half-quantity assessment of inflammatory infiltrate and of the stages of atrophic changes intensity was carried out in GM histological preparations, received from the antral part and gastric body, using visual-analogous scale.Results of research. At the comparison of Нр- colonization frequency between groups it was established, that the number of Нр – positive patients with NAG among I group was 1,5 times less (c2=8,14, р=0,032), than in ІІ group. It was established, that in І group at both non-atrophic and atrophic gastritis Нр-infection did not influence the intensity of disease. But at CG without concomitant pathology the integral index of inflammation in Нр-positive persons was 1,8 times higher (р<0,05), than in Нр-negative ones. The decrease of GM parenchyma thickness was observed in patients of both groups at the atrophy progression: in I group with AG the GM thickness in gastric body was 1,5 less than at NAG (р<0,05), the increase of stroma part in 1,6 times (р<0,05) comparing with NAG was observed in II group at AG.Conclusions. At NAG, associated with OA the number of Нр – positive patients was 1,5 times less (c2=8,14, р=0,032), than among patients with NAG without associated pathology. The intensity of inflammation in GM at CG in combination with OA in Нр-positive and Нр-negative patients did not essentially differ, at the same time at CG without concomitant pathology the integral index of inflammation in Нр-positive persons was 1,8times higher(р<0,05), than in Нр-negative ones. The progression of GM atrophy was characterized with the decrease of parenchyma thickness, not depending on concomitant pathology

В результаті проведеного дослідження встановлено, що перебіг хронічного гастриту у хворих хронічний гастрит (ХГ), які отримують селективні НПЗП з приводу супутнього остеоартрозу характеризується зменшенням інтенсивності запалення у слизової оболонки шлунка (порівняно з пацієнтами на ХГ без супутньої патології) та збільшенням частки строми, паралельно з прогресуванням атрофічних змін