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The influence of a course injection of melatonin on the hormonal activity of the hypophyseal-thyroid system in old rats with age-related hypophyroidism

The influence of a course injection of melatonin on the hormonal activity of the hypophyseal-thyroid system in old rats with age-related hypophyroidism

Abstract

Changes of the hormonal activity of the hypophyseal-thyroid system under the influence of a course injection of melatonin in physiological doses have been studied on old rats (18-20 months) of the Wistar population with age-related hypothyroidism. It is shown, that making up for the age-related deficiency of melatonin in an old organism causes a dose-dependent stimulating action on the hormonal activity of the thyroid gland, and this influence is direct as the thyrotropic function of the hypophysis is not involved in this particular process.

На старых крысах 18-20 мес. популяции Wistar с возрастным гипотиреозом изучены изменения гормональной активности гипофизарно-тиреоидной системы под влиянием курсового введения мелатонина в физиологических дозах. Показано, что восполнение возрастного дефицита мелатонина в старом организме вызывает дозозависимое стимулирующее действие на гормональную активность щитовидной железы, причем это влияние прямое, поскольку тиреотропная функция гипофиза не вовлекается в данный процесс.

На старих щурах 18-20 міс. популяції Wistar із віковим гіпотиреозом вивчені зміни гормональної активності гіпофізарно-тиреоїдної системи під впливом курсового уведення мелатоніну у фізіологічних дозах. Показано, що поповнення вікового дефіциту мелатоніну в старому організмі викликає дозозалежний стимулювальний вплив на гормональну активність щитоподібної залози, причому цей вплив прямий, оскільки тиреотропна функція гіпофіза не залучається в даний процес.

Keywords

гипофиз; щитовидная железа; гипотиреоз; мелатонин, гіпофіз; щитоподібна залоза; гіпотиреоз; мелатонін, hypophysis; thyroid gland; hypophyrosis; melatonin

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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