publication . Article . Other literature type . 2004

Expression of the RND-Type Efflux Pump AdeABC in Acinetobacter baumannii Is Regulated by the AdeRS Two-Component System

Marchand, I.; Damier-Piolle, L.; Courvalin, P.; Lambert, T.;
Open Access
  • Published: 01 Sep 2004 Journal: Antimicrobial Agents and Chemotherapy, volume 48, pages 3,298-3,304 (issn: 0066-4804, eissn: 1098-6596, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>The AdeABC pump of <jats:italic>Acinetobacter baumannii</jats:italic> BM4454, which confers resistance to various antibiotic classes including aminoglycosides, is composed of the AdeA, AdeB, and AdeC proteins; AdeB is a member of the RND superfamily. The <jats:italic>adeA</jats:italic>, <jats:italic>adeB</jats:italic>, and <jats:italic>adeC</jats:italic> genes are contiguous and adjacent to <jats:italic>adeS</jats:italic> and <jats:italic>adeR</jats:italic>, which are transcribed in the opposite direction and which specify proteins homologous to sensors and regulators of two-component systems, respectively (S. Magnet, P....
Subjects
free text keywords: Pharmacology (medical), Pharmacology, Infectious Diseases, Acinetobacter baumannii, biology.organism_classification, biology, Genetics, Microbiology, Plasmid, Two-component regulatory system, Efflux, Regulator gene, Stringent response, Molecular biology, Mutant, Gene, Mechanisms of Action: Physiological Effects
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