publication . Article . 2007

Karakterisering af bromadiolon resistens hos en dansk stamme af brune rotter, Rattus norvegicus, vha. lever gen ekspression analyse af gener involveret vitamin K-afhængig gamma-carboxylation

Mette Drude Markussen; Ann-Charlotte Heiberg; Merete Fredholm; Michael Kristensen;
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  • Published: 01 Jan 2007
Abstract
<p>Anticoagulant agents, such as warfarin and bromadiolone, are used to control populations of Norway rats (<em>Rattus norvegicus</em>). The anticoagulants compromise the blood-coagulation process by inhibiting the vitamin K<sub>2,3 </sub>epoxide reductase enzyme complex (VKOR). Mutations in the VKORC1 gene, encoding a VKOR protein, are believed to confer anticoagulant resistance in European strains of rats, whereas hepatic over-expression of calumenin has been suggested responsible for warfarin-resistance in an US rat strain. To characterize the resistance mechanism in a Danish bromadiolone-resistant strain of rats (with an Y139C-VKORC1 mutation), we compared V...
Subjects
free text keywords: Rattus norvegicus; Anticoagulant resistance; Bromadiolone; Vitamin K2,3 epoxide reductase subunit 1(VKORC1); Calumenin; Liver gene expression, Chemistry, Biochemistry, Molecular biology, VKORC1 Gene, Reductase, Bromadiolone, chemistry.chemical_compound, Gene expression, Gene, NAD(P)H dehydrogenase, VKORC1, Gene expression profiling
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publication . Article . 2007

Karakterisering af bromadiolon resistens hos en dansk stamme af brune rotter, Rattus norvegicus, vha. lever gen ekspression analyse af gener involveret vitamin K-afhængig gamma-carboxylation

Mette Drude Markussen; Ann-Charlotte Heiberg; Merete Fredholm; Michael Kristensen;