publication . Article . 2018

telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma

Lade-Keller, Johanne; Yuusufi, Sakineh; Riber-Hansen, Rikke; Steiniche, Torben; Stougaard, Magnus;
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  • Published: 01 Oct 2018 Journal: Melanoma Research (issn: 0960-8931, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
<p>The aims of this study were to assess the prognostic potential of solar elastosis grading and telomerase reverse transcriptase (TERT) promoter mutations (TERTp) in melanoma and to evaluate whether an association between solar elastosis and TERTp exists. Solar elastosis in the dermis was evaluated in hematoxylin and eosin-stained whole slides from 486 malignant melanomas. Pyrosequencing was used to detect TERTp in 189 samples. There was no association between solar elastosis and TERTp (P=0.3). Severe elastosis was associated with older age (P&lt;0.0001), ulceration (P=0.03), and location in the head/neck region (P&lt;0.0001). The absence of elastosis was assoc...
Subjects
free text keywords: BRAF, elastosis, mitogen-activated protein kinase pathway, mutation, p16, prognosis, pyrosequencing, Cancer Research, Oncology, Dermatology, Melanoma, medicine.disease, medicine, Telomerase reverse transcriptase, Pathology, medicine.medical_specialty, business.industry, business
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