publication . Article . 2017

Measurement of platelet aggregation, independently of patient platelet count: a flow-cytometric approach

Pernille Just Vinholt; Henrik Frederiksen; Anne-Mette Hvas; Ulrik Sprogøe; Christian Nielsen;
Open Access
  • Published: 01 Jan 2017
  • Publisher: Wiley
  • Country: Denmark
Abstract
Essentials •Platelet function may influence bleeding risk in thrombocytopenia, but useful tests are needed. •A flow cytometric platelet aggregation test independent of the patient platelet count was made. •Platelet aggregation was reduced in thrombocytopenic patients with hematological cancer. •High platelet aggregation ruled out bleeding tendency in thrombocytopenic patients. Summary Background Methods for testing platelet aggregation in thrombocytopenia are lacking. Objective To establish a flow-cytometric test of in vitro platelet aggregation independently of the patient's platelet count, and examine the association of aggregation with a bleeding history in t...
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Subjects
free text keywords: Hematology, Flow cytometry, Hematologic neoplasms, Methods, Platelet aggregation, Thrombocytopenia, Journal Article, Platelet disorder, Antiplatelet drug, medicine.medical_treatment, medicine, Gastroenterology, medicine.medical_specialty, business.industry, business, Thrombin, medicine.drug, Platelet activation, Interquartile range, P-selectin, Internal medicine, Platelet, Mean platelet volume
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