publication . Other literature type . Article . 1989

Physical properties of the Creutzfeldt-Jakob disease agent.

Theodoros Sklaviadis; Manuelidis L; Ee, Manuelidis;
Open Access English
  • Published: 01 Mar 1989
In this report, we present the first physical characterization of the Creutzfeld-Jakob disease agent. Preparations with high yields of infectivity (assayed infectious units) were obtained by a novel, gentle procedure in which initially sedimenting Gp34 ("prion" protein) was disaggregated by a variety of criteria with no subsequent loss of infectivity. Studies with this preparation indicate that most of the Creutzfeld-Jakob disease agent has both a viruslike size and density. In velocity sedimentation and isopycnic sucrose gradients, infectivity comigrated with nucleic acid-protein complexes of appreciable size.
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Other literature type . 1989
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