Balancing repair and tolerance of DNA damage caused by alkylating agents

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Fu, Dragony; Calvo, Jennifer A.; Samson, Leona D.;
  • Publisher: Nature Publishing Group
  • Related identifiers: doi: 10.1038/nrc3185
  • Subject:
    mesheuropmc: lipids (amino acids, peptides, and proteins)

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision rep... View more
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