publication . Article . Other literature type . 2012

Balancing repair and tolerance of DNA damage caused by alkylating agents

Dragony Fu; Jennifer A. Calvo; Leona D. Samson;
Open Access
  • Published: 12 Jan 2012
  • Publisher: Springer Science and Business Media LLC
  • Country: United States
Abstract
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue an...
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Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Cancer Research, Oncology, Article, DNA mismatch repair, Direct DNA damage, Biology, Epigenetics, Genetics, Base excision repair, Mode of action, Mutation, medicine.disease_cause, medicine, DNA repair, DNA damage
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Article . 2012
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Europe PubMed Central
Other literature type . 2012
http://dx.doi.org/10.1038/nrc3...
Other literature type . 2012
Provider: Datacite
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