Designing Robustness to Temperature in a Feedforward Loop Circuit

Preprint, Part of book or chapter of book OPEN
Murray, Richard; Sen, Shaunak; Kim, Jongmin;
(2014)

Incoherent feedforward loops represent important biomolecular circuit elements capable of a rich set of dynamic behavior including adaptation and pulsed responses. Temperature can modulate some of these properties through its effect on the underlying reaction rate param... View more
  • References (16)
    16 references, page 1 of 2

    [1] N. Barkai and S. Leibler, “Robustness in simple biochemical networks,” Nature, vol. 387, pp. 913-917, June 1997.

    [2] S. Cardinale and A. P. Arkin, “Contextualizing context for synthetic biology-identifying causes of failure of synthetic biological systems,” Biotechnology journal, vol. 7, pp. 856-866, July 2012.

    [3] M. Nakajima, K. Imai, H. Ito, T. Nishiwaki, Y. Murayama, H. Iwasaki, T. Oyama, and T. Kondo, “Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro,” Science, vol. 308, no. 5720, pp. 414-5, 2005.

    [4] J. Stricker, S. Cookson, M. R. Bennett, W. H. Mather, L. S. Tsimring, and J. Hasty, “A fast, robust and tunable synthetic gene oscillator,” Nature, vol. 456, pp. 516-519, Nov. 2008.

    [5] A. B. Reyes, J. S. Pendergast, and S. Yamazaki, “Mammalian peripheral circadian oscillators are temperature compensated,” J Biol Rhythms, vol. 23, pp. 95-98, 2008.

    [6] O. Oleksiuk, V. Jakovljevic, N. Vladimirov, R. Carvalho, E. Paster, W. S. Ryu, Y. Meir, N. S. Wingreen, M. Kollmann, and V. Sourjik, “Thermal robustness of signaling in bacterial chemotaxis,” Cell, vol. 145, pp. 312-21, 2011.

    [7] S. Mangan and U. Alon, “Structure and function of the feed-forward loop network motif,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, pp. 11980-11985, Oct. 2003.

    [8] S. S. Shen-Orr, R. Milo, S. Mangan, and U. Alon, “Network motifs in the transcriptional regulation network of escherichia coli,” Nature genetics, vol. 31, pp. 64-68, May 2002.

    [9] J. J. Tyson, K. C. Chen, and B. Novak, “Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell,” Current opinion in cell biology, vol. 15, pp. 221-231, Apr. 2003.

    [10] W. Ma, A. Trusina, H. El-Samad, W. A. Lim, and C. Tang, “Defining network topologies that can achieve biochemical adaptation,” Cell, vol. 138, pp. 760-773, Aug. 2009.

  • Related Organizations (2)
  • Metrics
Share - Bookmark