Bifunctional Rhodium Intercalator Conjugates as Mismatch-Directing DNA Alkylating Agents

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Schatzschneider, Ulrich; Barton, Jacqueline K.;
  • Publisher: American Chemical Society

A conjugate of a DNA mismatch-specific rhodium intercalator, containing the bulky chrysenediimine ligand, and an aniline mustard has been prepared, and targeting of mismatches in DNA by this conjugate has been examined. The preferential alkylation of mismatched over ful... View more
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