publication . Article . 2012

Direct Atomic Force Microscopy Observation of DNA Tile Crystal Growth at the Single-Molecule Level

Evans, Constantine G.; Hariadi, Rizal F.; Winfree, Erik;
Open Access
  • Published: 27 Jun 2012
  • Publisher: American Chemical Society
  • Country: United States
Abstract
While the theoretical implications of models of DNA tile self-assembly have been extensively researched and such models have been used to design DNA tile systems for use in experiments, there has been little research testing the fundamental assumptions of those models. In this paper, we use direct observation of individual tile attachments and detachments of two DNA tile systems on a mica surface imaged with an atomic force microscope (AFM) to compile statistics of tile attachments and detachments. We show that these statistics fit the widely used kinetic Tile Assembly Model and demonstrate AFM movies as a viable technique for directly investigating DNA tile sys...
Subjects
arXiv: Quantitative Biology::Biomolecules
ACM Computing Classification System: Hardware_ARITHMETICANDLOGICSTRUCTURES
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Article . 2012
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