publication . Other literature type . Article . 2010

Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates.

Sean M. A. Kedrowski; Dennis A. Dougherty;
Open Access English
  • Published: 17 Sep 2010
  • Country: United States
Abstract
The reductive deoxygenation of acyl phosphonates using a Wolff−Kishner-like sequence is described. This transformation allows direct access to alkyl phosphonates from acyl phosphonates at room temperature. The method can be combined with acyl phosphonate synthesis into a one pot, four-step procedure for the conversion of carboxylic acids into alkyl phosphonates. The methodology works well for a variety of aliphatic acids and shows a functional group tolerance similar to that of other hydrazone-forming reactions.
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Article, Chemistry, Alkyl, chemistry.chemical_classification, Organic chemistry, Oxalyl chloride, chemistry.chemical_compound, Deoxygenation, Physical and Theoretical Chemistry, Biochemistry, Acylation, Photochemistry, Phosphonate, Molecule, Organophosphonates, Oxidation reduction
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publication . Other literature type . Article . 2010

Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates.

Sean M. A. Kedrowski; Dennis A. Dougherty;