Completion of a Programmable DNA-Binding Small Molecule Library

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Hsu, Carey F.; Phillips, John W.; Trauger, John W.; Farkas, Michelle E.; Belitsky, Jason M.; Heckel, Alexander; Olenyuk, Bogdan Z.; Puckett, James W.; Wang, Clay C. C.; Dervan, Peter B.;
  • Publisher: Elsevier

Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules have been shown to enter the nu... View more
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