publication . Preprint . Article . 2011

Encapsulation by Janus spheroids

Wei Li; Ya Liu; Genevieve Brett; James D. Gunton;
Open Access English
  • Published: 14 Dec 2011
Abstract
The micro/nano encapsulation technology has acquired considerable attention in the fields of drug delivery, biomaterial engineering, and materials science. Based on recent advances in chemical particle synthesis, we propose a primitive model of an encapsulation system produced by the self-assembly of Janus oblate spheroids, particles with oblate spheroidal bodies and two hemi-surfaces coded with dissimilar chemical properties. Using Monte Carlo simulation, we investigate the encapsulation system with spherical particles as encapsulated guests, for different densities. We study the anisotropic effect due to the encapsulating agent's geometric shape and chemical c...
Subjects
free text keywords: Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, General Chemistry, Condensed Matter Physics, Monte Carlo method, Biomaterial, Particle, Spheroid, Nanotechnology, Geometric shape, Janus, Nano-, Chemistry, Drug delivery
Related Organizations
43 references, page 1 of 3

wel208@lehigh.edu [1] Mathiowitz, E. et al. Biologically erodable microspheres

as potential oral drug delivery systems. Nature. 386, 410-

414 (1997). [2] Sutton, D. et al. Functionalized micellar systems for can-

cer targeted drug delivery. Pharmaceutical Research. 24,

1029-1046 (2007). [3] Cohen, S. et al. Controlled delivery systems for proteins

maceutical Research. 8, 713-720 (1991). [4] De Jong, W. H. & Borm, P. JA. Drug delivery and

Journal of Nanomedicine. 133, 133-149 (2008). [5] Tyrrell, Z. L., Shen, Y. & Radosz, M. Fabrication of mi-

ence. 35, 1128-1143 (2010). [6] Leach, K. J., Takahashi, S. & Mathiowitz, E. Degrada-

P(CPP:SA)20:80. II. In vivo degradation. Biomaterials.

19, 1981-1988 (1998). [7] Jaklenec, A. et al. Novel sca olds fabricated from

materials. 29, 185-192 (2008). [8] Singh, M. et al. Microsphere-based sca olds for cartilage

tissue engineering: using sub-critical CO2 as a sintering

agent. Acta Biomater. 6, 137-143 (2010). [9] Nair, L. S. & Laurencin, C. T. Polymers as biomaterials

Biochem Eng Biotechnol. 102, 47-90 (2006). [10] Shi, X. et al. Sintered microsphere sca olds for controlled

release and tissue engineering. Pharm Res. 28, 1224-1228

43 references, page 1 of 3
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publication . Preprint . Article . 2011

Encapsulation by Janus spheroids

Wei Li; Ya Liu; Genevieve Brett; James D. Gunton;