publication . Preprint . Conference object . Other literature type . 2017

MotifMark: Finding Regulatory Motifs in DNA Sequences

Hassanzadeh, Hamid Reza; Kolhe, Pushkar; Isbell, Charles L.; Wang, May D.;
Open Access
  • Published: 05 May 2017
  • Publisher: Cold Spring Harbor Laboratory
Abstract
<jats:title>Abstract</jats:title><jats:p>The interaction between proteins and DNA is a key driving force in a significant number of biological processes such as transcriptional regulation, repair, recombination, splicing, and DNA modification. The identification of DNA-binding sites and the specificity of target proteins in binding to these regions are two important steps in understanding the mechanisms of these biological activities. A number of high-throughput technologies have recently emerged that try to quantify the affinity between proteins and DNA motifs. Despite their success, these technologies have their own limitations and fall short in precise charac...
Subjects
free text keywords: Haystack, Binding site, DNA sequencing, Computational biology, RNA splicing, Genetics, DNA, chemistry.chemical_compound, chemistry, Plasma protein binding, Transcription factor, Biology, DNA microarray, Computer vision, Artificial intelligence, business.industry, business, Computer science, Quantitative Biology - Quantitative Methods, Computer Science - Learning, Quantitative Biology - Genomics, Article
Related Organizations
Funded by
NIH| Atlanta Clinical and Translational Science Institute (ACTSI) Renewal
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UL1TR000454-07
  • Funding stream: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
,
NIH| Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA163256-02
  • Funding stream: NATIONAL CANCER INSTITUTE

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