publication . Preprint . Conference object . Other literature type . 2017

MotifMark: Finding Regulatory Motifs in DNA Sequences

Hassanzadeh, Hamid Reza; Kolhe, Pushkar; Isbell, Charles L.; Wang, May D.;
Open Access
  • Published: 05 May 2017
  • Publisher: Cold Spring Harbor Laboratory
<jats:title>Abstract</jats:title><jats:p>The interaction between proteins and DNA is a key driving force in a significant number of biological processes such as transcriptional regulation, repair, recombination, splicing, and DNA modification. The identification of DNA-binding sites and the specificity of target proteins in binding to these regions are two important steps in understanding the mechanisms of these biological activities. A number of high-throughput technologies have recently emerged that try to quantify the affinity between proteins and DNA motifs. Despite their success, these technologies have their own limitations and fall short in precise charac...
free text keywords: Quantitative Biology - Quantitative Methods, Computer Science - Learning, Quantitative Biology - Genomics, Article
Funded by
NIH| Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA163256-02
NIH| Atlanta Clinical and Translational Science Institute (ACTSI) Renewal
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UL1TR000454-07

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