publication . Preprint . 2014

Filovirus Glycoprotein Sequence, Structure and Virulence

Phillips, J. C.;
Open Access English
  • Published: 26 Sep 2014
Leading Ebola subtypes exhibit a wide mortality range, here explained at the molecular level by using fractal hydropathic scaling of amino acid sequences based on protein self-organized criticality. Specific hydrophobic features in the hydrophilic mucin-like domain suffice to account for the wide mortality range. Significance statement: Ebola virus is spreading rapidly in Africa. The connection between protein amino acid sequence and mortality is identified here.
Medical Subject Headings: viruses
free text keywords: Quantitative Biology - Biomolecules
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