publication . Preprint . Article . 2015

Certain amplified genomic-DNA fragments (AGFs) may be involved in cell cycle progression and chloroquine is found to induce the production of cell-cycle-associated AGFs (CAGFs) in Plasmodium falciparum

Gao-De Li;
Open Access English
  • Published: 12 Oct 2015
It is well known that cyclins are a family of proteins that control cell-cycle progression by activating cyclin-dependent kinase. Based on our experimental results, we propose here a novel hypothesis that certain amplified genomic-DNA fragments (AGFs) may also be required for the cell cycle progression of eukaryotic cells and thus can be named as cell-cycle-associated AGFs (CAGFs). Like fluctuation in cyclin levels during cell cycle progression, these CAGFs are amplified and degraded at different points of the cell cycle. The functions of CAGFs are unknown, but we speculate that CAGFs might be involved in regulation of gene expression, genome protection, and for...
free text keywords: Quantitative Biology - Subcellular Processes, Quantitative Biology - Quantitative Methods, genomic DNA, Cyclin, Regulation of gene expression, Plasmodium falciparum, biology.organism_classification, biology, Cell cycle, Kinase, Cell biology, Chloroquine, medicine.drug, medicine, Genome
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