Evolutionary dynamics of adult stem cells: Comparison of random and immortal strand segregation mechanisms

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Tannenbaum, Emmanuel; Sherley, James L.; Shakhnovich, Eugene I.;

This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer. We consider two modes of chromosome segregation: (1) ... View more
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