publication . Preprint . 2014

Rigidity and flexibility in protein-protein interaction networks: a case study on neuromuscular disorders

Sharma, Ankush; Ferraro, Maria Brigida; Maiorano, Francesco; Blanco, Francesca Del Vecchio; Guarracino, Mario Rosario;
Open Access English
  • Published: 10 Feb 2014
Mutations in proteins can have deleterious effects on a protein's stability and function, which ultimately causes particular diseases. Genetically inherited muscular dystrophies (MDs) include several genetic diseases, which cause increasing weakness in muscles and disability to perform muscular functions progressively. Different types of mutations in the gene coding translates into defunct proteins cause different neuro-muscular diseases. Defunct protein interactions in human proteome may cause a stress to its neighboring proteins and its modules. We therefore aimed to understand the effects of mutated proteins on interacting partners in different muscular dystr...
free text keywords: Quantitative Biology - Molecular Networks
Download from
57 references, page 1 of 4

1. Amino MJ, Daro RB, Chad DA: Neuromuscular Disorders, Overview 2003, :494{500, [http: //].

2. Bonaldo P, Sandri M: Cellular and molecular mechanisms of muscle atrophy. Disease models & mechanisms 2013, 6:25{39, []. [OpenAIRE]

3. McNally EM, Pytel P: Muscle diseases: the muscular dystrophies. Annual review of pathology 2007, 2:87{109, []. [OpenAIRE]

4. Hara Y, Balci-Hayta B, Yoshida-Moriguchi T, Kanagawa M, de Bernabe D, GundeAY li H, Willer T, Satz JS, Crawford RW, Burden SJ, Kunz S, Oldstone MBA, Accardi A, Talim B, Muntoni F, TopaloA Y lu H, Dincer P, Campbell KP: A Dystroglycan Mutation Associated with Limb-Girdle Muscular Dystrophy. New England Journal of Medicine 2011, 364(10):939{946, [ 10.1056/NEJMoa1006939].

5. Singh SM, Kongari N, Cabello-Villegas J, Mallela KMG: Missense mutations in dystrophin that trigger muscular dystrophy decrease protein stability and lead to cross-beta aggregates. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(34):15069{ 74, [].

6. Csermely P, Sandhu KS, Hazai E, Hoksza Z, Kiss HJM, Miozzo F, Veres DV, Piazza F, Nussinov R: Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review. Current protein peptide science 2011, 13:27, [].

7. Zhu X, Gerstein M, Snyder M: Getting connected: analysis and principles of biological networks. Genes & development 2007, 21(9):1010{24, [].

8. Mihalik A, Csermely P: Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. PLoS Computational Biology 2011, 7(10):24, []. [OpenAIRE]

9. Newman MEJ, Girvan M: Finding and evaluating community structure in networks. Phys. Rev. E 2004, 69:026113, [].

10. Rives AW, Galitski T: Modular organization of cellular networks. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(3):1128{33, [ content/100/3/1128]. [OpenAIRE]

11. Barabasi a: Emergence of Scaling in Random Networks. Science 1999, 286(5439):509{512, [http: //].

12. Jeong H, Mason S, Barabasi A, Oltvai Z: Lethality and centrality in protein networks : Abstract : Nature. Nature 2001, 411(6833):41{42. [OpenAIRE]

13. Watts DJ, Strogatz SH: Collective dynamics of "small-world"networks. Nature 1998, 393(6684):440{442, [].

14. Narayanan S: The Betweenness Centrality Of Biological Networks A Study of Betweenness Centrality. PhD thesis, Virginia Polytechnic Institute 2005.

15. Yu H, Kim PM, Sprecher E, Trifonov V, Gerstein M: The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics. PLoS Computational Biology 2007, 3(4):8, [].

57 references, page 1 of 4
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue