publication . Preprint . 2017

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum

Li, Gao-De;
Open Access English
  • Published: 07 Feb 2017
Abstract
Comment: 11 pages, 1 figure, 1 table
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Quantitative Biology - Subcellular Processes
Download from
39 references, page 1 of 3

[1] Packard, R.M. (2014) The Origins of Antimalarial-Drug Resistance. New England Journal of Medicine, 371, 397-399. https://doi.org/10.1056/NEJMp1403340

[2] Zhang, Y., Liao, Z., Zhang, L.J. and Xiao, H.T. (2015) The Utility of Chloroquine in Cancer Therapy. Current Medical Research and Opinion, 31, 1009-1013. https://doi.org/10.1185/03007995.2015.1025731

Antony, H.A. and Parija, S.C. (2016) Antimalarial Drug Resistance: An Overview. Tropical Parasitology, 6, 30-41. https://doi.org/10.4103/2229-5070.175081 [OpenAIRE]

Meshnick, S.R. (1990) Chloroquine as Intercalator: A Hypothesis Revived. Parasitology Today, 6, 77-79. https://doi.org/10.1016/0169-4758(90)90215-P

[5] Picot, S., Burnod, J., Bracchi, V., Chumpitazi, B.F. and Ambroise-Thomas, P. (1997) Apoptosis Related to Chloroquine Sensitivity of the Human Malaria Parasite Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 590-591. https://doi.org/10.1016/S0035-9203(97)90039-0

[6] Trotta, R.F., Brown, M.L., Terrell, J.C. and Geyer, J.A. (2004) Defective DNA Repair as a Potential Mechanism for the Rapid Development of Drug Resistance in Plasmodium falciparum. Biochemistry, 43, 4885-4891. https://doi.org/10.1021/bi0499258

Gupta, D.K., Patra, A.T., Zhu, L., Gupta, A.P. and Bozdech, Z. (2016) DNA Damage Regulation and Its Role in Drug-Related Phenotypes in the Malaria Parasites. Scientific Reports, 6, 23603. https://doi.org/10.1038/srep23603

[8] Li, G.D. (2006) Nucleus May Be the Key Site of Chloroquine Antimalarial Action and Resistance Development. Medical Hypotheses, 67, 323-326. https://doi.org/10.1016/j.mehy.2006.02.008

[9] Li, G.D. (2007) Plasmodium falciparum Chloroquine Resistance Marker Protein (Pfcrmp) May Be a Chloroquine Target Protein in Nucleus. Medical Hypotheses, 68, 332-334. https://doi.org/10.1016/j.mehy.2006.07.016

[10] Li, G.D. (2008) Pfcrmp May Play a Key Role in Chloroquine Antimalarial Action and Resistance Development. Medical Hypotheses and Research, 4, 69-73.

[11] Li, G.D. (2016) Certain Amplified Genomic-DNA Fragments (AGFs) May Be Involved in Cell Cycle Progression and Chloroquine Is Found to Induce the Production of Cell-Cycle-Associated AGFs (CAGFs) in Plasmodium falciparum. Open Ac-

[14] Li, G.D. (2016) Genoautotomy (Genome “Self-Injury”) in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress. Open Access Library Journal , 3, e2946. https://doi.org/10.4236/oalib.1102946

[15] Rakoczy, P.E. (2001) Antisense DNA Technology. Methods in Molecular Medicine, 47, 89-104.

[16] Billen, D. (1990) Spontaneous DNA Damage and Its Significance for the “Negligible Dose” Controversy in Radiation Protection. Radiation Research , 124, 242-245. https://doi.org/10.2307/3577872

[17] Li, G.D. (2016) “Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells. Open Access Library Journal , 3, e2595. https://doi.org/10.4236/oalib.1102595

39 references, page 1 of 3
Abstract
Comment: 11 pages, 1 figure, 1 table
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Quantitative Biology - Subcellular Processes
Download from
39 references, page 1 of 3

[1] Packard, R.M. (2014) The Origins of Antimalarial-Drug Resistance. New England Journal of Medicine, 371, 397-399. https://doi.org/10.1056/NEJMp1403340

[2] Zhang, Y., Liao, Z., Zhang, L.J. and Xiao, H.T. (2015) The Utility of Chloroquine in Cancer Therapy. Current Medical Research and Opinion, 31, 1009-1013. https://doi.org/10.1185/03007995.2015.1025731

Antony, H.A. and Parija, S.C. (2016) Antimalarial Drug Resistance: An Overview. Tropical Parasitology, 6, 30-41. https://doi.org/10.4103/2229-5070.175081 [OpenAIRE]

Meshnick, S.R. (1990) Chloroquine as Intercalator: A Hypothesis Revived. Parasitology Today, 6, 77-79. https://doi.org/10.1016/0169-4758(90)90215-P

[5] Picot, S., Burnod, J., Bracchi, V., Chumpitazi, B.F. and Ambroise-Thomas, P. (1997) Apoptosis Related to Chloroquine Sensitivity of the Human Malaria Parasite Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 590-591. https://doi.org/10.1016/S0035-9203(97)90039-0

[6] Trotta, R.F., Brown, M.L., Terrell, J.C. and Geyer, J.A. (2004) Defective DNA Repair as a Potential Mechanism for the Rapid Development of Drug Resistance in Plasmodium falciparum. Biochemistry, 43, 4885-4891. https://doi.org/10.1021/bi0499258

Gupta, D.K., Patra, A.T., Zhu, L., Gupta, A.P. and Bozdech, Z. (2016) DNA Damage Regulation and Its Role in Drug-Related Phenotypes in the Malaria Parasites. Scientific Reports, 6, 23603. https://doi.org/10.1038/srep23603

[8] Li, G.D. (2006) Nucleus May Be the Key Site of Chloroquine Antimalarial Action and Resistance Development. Medical Hypotheses, 67, 323-326. https://doi.org/10.1016/j.mehy.2006.02.008

[9] Li, G.D. (2007) Plasmodium falciparum Chloroquine Resistance Marker Protein (Pfcrmp) May Be a Chloroquine Target Protein in Nucleus. Medical Hypotheses, 68, 332-334. https://doi.org/10.1016/j.mehy.2006.07.016

[10] Li, G.D. (2008) Pfcrmp May Play a Key Role in Chloroquine Antimalarial Action and Resistance Development. Medical Hypotheses and Research, 4, 69-73.

[11] Li, G.D. (2016) Certain Amplified Genomic-DNA Fragments (AGFs) May Be Involved in Cell Cycle Progression and Chloroquine Is Found to Induce the Production of Cell-Cycle-Associated AGFs (CAGFs) in Plasmodium falciparum. Open Ac-

[14] Li, G.D. (2016) Genoautotomy (Genome “Self-Injury”) in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress. Open Access Library Journal , 3, e2946. https://doi.org/10.4236/oalib.1102946

[15] Rakoczy, P.E. (2001) Antisense DNA Technology. Methods in Molecular Medicine, 47, 89-104.

[16] Billen, D. (1990) Spontaneous DNA Damage and Its Significance for the “Negligible Dose” Controversy in Radiation Protection. Radiation Research , 124, 242-245. https://doi.org/10.2307/3577872

[17] Li, G.D. (2016) “Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells. Open Access Library Journal , 3, e2595. https://doi.org/10.4236/oalib.1102595

39 references, page 1 of 3
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