publication . Preprint . 2011

The Structural Stability of Wild-type Horse Prion Protein - Molecular Dynamics Studies

Zhang, Jiapu;
Open Access English
  • Published: 24 Apr 2011
Abstract
Prion diseases {\it (e.g. Creutzfeldt-Jakob disease (CJD), variant CJD (vCJD), Gerstmann-Str$\ddot{\text{a}}$ussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI) and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE or `mad-cow' disease) and chronic wasting disease (CWD) in cattles)} are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. However, by now there have not been some effective therapeutic approaches or medications to treat all these prion diseases. Rabbits, dogs, and horses are the only mammalian species reported to be resistant to infection from prion diseases isolated from ...
Subjects
Medical Subject Headings: nervous system diseasesanimal diseases
free text keywords: Quantitative Biology - Biomolecules, Physics - Biological Physics, Physics - Medical Physics
Related Organizations
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49 references, page 1 of 4

1. A. Aguzzi and M.. Heikenwalder. Nat Rev Microbiol 4, 765-775 (2006).

2. S. B. Prusiner. Proc Natl Acad Sci USA 95, 13363-13383 (1998).

3. C. Weissmann. Microbiol 2, 861-871 (2004).

4. M. Polymenidoua, H. Trusheimb, L. Stallmacha, R. Moosa, J. A. Julius, G. Mielea, C. Lenzbauerb, and A. Aguzzia. Vaccine 26, 2601-2614 (2008). [OpenAIRE]

5. I. Vorberg, H. G. Martin, P. Eberhard, and A. P. Suzette. J Virol 77, 2003-2009 (2003).

6. D. R. Perez, F. F. Damberger, and K. Wuthrich. J Mol Biol 400(2), 121-128 (2010).

7. J. Yoon, S. Jang, K. Lee, and S. Shin. J Biomol Struct Dyn 27, 259-269 (2009).

8. D. Ilda, C. Giovanni, and D. Alessandro. J Biomol Struct Dyn 27, 307-317 (2009).

9. A. Cordomi and J. J Perez. J Biomol Struct Dyn 27, 127-147 (2009).

10. L. K. Chang, J. H. Zhao, H. L. Liu, K. T. Liu, J. T. Chen, W. B. Tsai, and Y. Ho. J Biomol Struct Dyn 26, 731-740 (2009).

11. J. H. Zhao, H. L. Liu, Y. F. Liu, H.Y. Lin, H. W. Fang, Y. Ho, and W. B Tsai. J Biomol Struct Dyn 26, 481-490 (2009).

12. P. S. Fang, J. H. Zhao, H. L. Liu, K. T. Liu, J. T. Chen, H. Y. Lin, C. H. Huang, and H. W. Fang. J Biomol Struct Dyn 26, 549-559 (2009).

13. P. N. Sunilkumar, D. G Nair, C. Sadasivan, and M. Haridas. J Biomol Struct Dyn 26, 491-496 (2009).

14. H. R. Bairagya, B. P. Mukhopadhyay, and K. Sekar. J Biomol Struct Dyn 27, 149-158 (2009).

15. M. S. Achary and H. A. Nagarajaram. J Biomol Struct Dyn 26, 609-623 (2009).

49 references, page 1 of 4
Abstract
Prion diseases {\it (e.g. Creutzfeldt-Jakob disease (CJD), variant CJD (vCJD), Gerstmann-Str$\ddot{\text{a}}$ussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI) and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE or `mad-cow' disease) and chronic wasting disease (CWD) in cattles)} are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. However, by now there have not been some effective therapeutic approaches or medications to treat all these prion diseases. Rabbits, dogs, and horses are the only mammalian species reported to be resistant to infection from prion diseases isolated from ...
Subjects
Medical Subject Headings: nervous system diseasesanimal diseases
free text keywords: Quantitative Biology - Biomolecules, Physics - Biological Physics, Physics - Medical Physics
Related Organizations
Download from
49 references, page 1 of 4

1. A. Aguzzi and M.. Heikenwalder. Nat Rev Microbiol 4, 765-775 (2006).

2. S. B. Prusiner. Proc Natl Acad Sci USA 95, 13363-13383 (1998).

3. C. Weissmann. Microbiol 2, 861-871 (2004).

4. M. Polymenidoua, H. Trusheimb, L. Stallmacha, R. Moosa, J. A. Julius, G. Mielea, C. Lenzbauerb, and A. Aguzzia. Vaccine 26, 2601-2614 (2008). [OpenAIRE]

5. I. Vorberg, H. G. Martin, P. Eberhard, and A. P. Suzette. J Virol 77, 2003-2009 (2003).

6. D. R. Perez, F. F. Damberger, and K. Wuthrich. J Mol Biol 400(2), 121-128 (2010).

7. J. Yoon, S. Jang, K. Lee, and S. Shin. J Biomol Struct Dyn 27, 259-269 (2009).

8. D. Ilda, C. Giovanni, and D. Alessandro. J Biomol Struct Dyn 27, 307-317 (2009).

9. A. Cordomi and J. J Perez. J Biomol Struct Dyn 27, 127-147 (2009).

10. L. K. Chang, J. H. Zhao, H. L. Liu, K. T. Liu, J. T. Chen, W. B. Tsai, and Y. Ho. J Biomol Struct Dyn 26, 731-740 (2009).

11. J. H. Zhao, H. L. Liu, Y. F. Liu, H.Y. Lin, H. W. Fang, Y. Ho, and W. B Tsai. J Biomol Struct Dyn 26, 481-490 (2009).

12. P. S. Fang, J. H. Zhao, H. L. Liu, K. T. Liu, J. T. Chen, H. Y. Lin, C. H. Huang, and H. W. Fang. J Biomol Struct Dyn 26, 549-559 (2009).

13. P. N. Sunilkumar, D. G Nair, C. Sadasivan, and M. Haridas. J Biomol Struct Dyn 26, 491-496 (2009).

14. H. R. Bairagya, B. P. Mukhopadhyay, and K. Sekar. J Biomol Struct Dyn 27, 149-158 (2009).

15. M. S. Achary and H. A. Nagarajaram. J Biomol Struct Dyn 26, 609-623 (2009).

49 references, page 1 of 4
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