publication . Preprint . 2017

REM sleep complicates period adding bifurcations from monophasic to polyphasic sleep behavior in a sleep-wake regulatory network model for human sleep

Kalmbach, K.; Booth, V.; Behn, C. G. Diniz;
Open Access English
  • Published: 16 Oct 2017
Abstract
The structure of human sleep changes across development as it consolidates from the polyphasic sleep of infants to the single nighttime sleep period typical in adults. Across this same developmental period, time scales of the homeostatic sleep drive, the physiological drive to sleep that increases with time spent awake, also change and presumably govern the transition from polyphasic to monophasic sleep behavior. Using a physiologically-based, sleep-wake regulatory network model for human sleep, we investigated the dynamics of wake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep during this transition by varying the homeostatic sleep drive time constan...
Subjects
free text keywords: Quantitative Biology - Neurons and Cognition
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Funded by
NSF| Collaborative research: Multiscale modeling of the physiological interactions between sleep and circadian systems
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1412571
  • Funding stream: Directorate for Mathematical & Physical Sciences | Division of Mathematical Sciences
,
NSF| Collaborative Research: Multiscale Modeling of the Physiological Interactions Between Sleep/Wake and Circadian Systems
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1412119
  • Funding stream: Directorate for Mathematical & Physical Sciences | Division of Mathematical Sciences
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