publication . Preprint . 2011

Inhibition of central insulin-receptor signaling by S961 causes hyperglycemia and glucose intolerance in rats

Ajit Vikram; Gopabandhu Jena;
Open Access
  • Published: 18 Feb 2011
Abstract
Genetic ablation studies confirmed the role of central insulin-receptor signaling (CIRS) in fuel metabolism. However, the need to examine the role of CIRS in glucose homeostasis under normal physiological condition is indispensable, as insulin affects the neuronal growth, differentiation and synaptic plasticity. Intracerebral administration of S961 induced hyperglycemia and glucose intolerance in normal rats, and provided direct evidence for the involvement of CIRS in the regulation of glucose homeostasis.
Subjects
free text keywords: Neuroscience, Pharmacology
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