publication . Article . Preprint . 2007

Solvent Induced Disulfide Bond Formation in 2,5-dimercapto-1,3,4-thiadiazole

Palanisamy Kalimuthu; Palraj Kalimuthu; S. Abraham John;
Open Access
  • Published: 15 Aug 2007 Journal: Nature Precedings (eissn: 1756-0357, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Disulfide bond formation is the decisive event in the protein folding to determine the conformation and stability of protein. To achieve this disulfide bond formation in vitro, we took 2,5-dimercapto-1,3,4-thiadiazole (DMcT) as a model compound. We found that disulfide bond formation takes place between two sulfhydryl groups of DMcT molecules in methanol. UV-Vis, FT-IR and mass spectroscopic as well as cyclic voltammetry were used to monitor the course of reaction. We proposed a mechanism for the solvent induced disulfide bond formation on the basis of the results we obtained.
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Medical Subject Headings: education
free text keywords: Molecular Cell Biology, Methanol, chemistry.chemical_compound, chemistry, Solvent, Protein folding, Cyclic voltammetry, Disulfide bond, 2 5 dimercapto 1 3 4 thiadiazole, Polymer chemistry, Molecule
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