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Publication . Article . 2006

Synthesis of L-2-amino-8-oxodecanoic acid: an amino acid component of apicidins

M. Lourdes Linares; F. Javier Agejas; Ramón Alajarín; Juan J. Vaquero; Julio Alvarez-Builla;
Open Access  
Published: 06 Jun 2006
Publisher: Thieme
Country: Spain
Abstract
The synthesis Of L-2-amino-8-oxodecanoic acid (Aoda) is described. This is a rare amino acid component of apicidins, a family of new cyclic tetrapeptides, inhibitors of histone deacetylase. Aoda was synthesised in seven steps from L-glutamic acid along with some derivatives. Universidad de Alcalá Fundación General de la Universidad de Alcalá FEDER
Subjects by Vocabulary

Microsoft Academic Graph classification: Chemistry Amino acid chemistry.chemical_classification Histone deacetylase Biochemistry Component (thermodynamics)

Subjects

Amino acid, Aoda, Apicidins, Histone deacetylase, Inhibitors, CIENCIA, Química orgánica, SCIENCE, Chemistry, organic, Organic Chemistry, Catalysis, Amino acid, Aoda, Apicidins, Histone deacetylase, Inhibitors, CIENCIA, Química orgánica, SCIENCE, Chemistry, organic

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