Synthesis of L-2-amino-8-oxodecanoic acid: an amino acid component of apicidins

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Linares de la Morena, María Lourdes; Agejas Chicharro, Francisco Javier; Alajarín Ferrández, Ramón; Vaquero López, Juan José; Álvarez-Builla Gómez, Julio; (2001)
  • Publisher: Thieme
  • Related identifiers: doi: 10.1055/s-2006-942395
  • Subject: Amino acid | Aoda | Apicidins | Histone deacetylase | Inhibitors | CIENCIA | Química orgánica | SCIENCE | Chemistry, organic

The synthesis Of L-2-amino-8-oxodecanoic acid (Aoda) is described. This is a rare amino acid component of apicidins, a family of new cyclic tetrapeptides, inhibitors of histone deacetylase. Aoda was synthesised in seven steps from L-glutamic acid along with some derivat... View more
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