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Bioaktivne molekule – policiklički derivati gvanidina
Copyright policy )Croatian Society of Chemical EngineersBioaktivne molekule – policiklički derivati gvanidina
Biological activity of different adamantane derivatives and their application has been described in various reviews. Similarly, many reviews deal with biological activity and application of guanidine compounds. However, up to now no review has been made concerning the guanidine derivatives of adamantane and other polycycles, compounds which incorporate both of these moieties in the same molecule. Therefore, a literature survey of polycyclic guanidine derivatives is here provided and their application as potential pharmacophores stressed.
Biološka aktivnost različitih adamantanskih derivata i njihova primjena opisane su u brojnim preglednim člancima. Isto tako, mnogi revijalni članci opisuju biološku aktivnost i primjenu gvanidinskih spojeva. Međutim do sada nije načinjen pregled koji bi se bavio gvanidinskim derivatima adamantana i drugih policikla, tj. spojevima koji sadrže obje navedene podjedinice u istoj molekuli. U ovom radu bit će stoga dan pregled policikličkih derivata gvanidina, i to s naglaskom na njihovu primjenu kao potencijalnih farmakofora.
- Ruđer Bošković Institute Croatia
Library of Congress Subject Headings: lcsh:Chemistry lcsh:QD1-999
Adamantan; policikli; gvanidin; bioaktivni spojevi; farmakofori, Adamantane; polycycles; guanidine; bioactive compounds; pharmacophores, Adamantane, polycycles, guanidine, bioactive compounds, pharmacophores
Adamantan; policikli; gvanidin; bioaktivni spojevi; farmakofori, Adamantane; polycycles; guanidine; bioactive compounds; pharmacophores, Adamantane, polycycles, guanidine, bioactive compounds, pharmacophores
Library of Congress Subject Headings: lcsh:Chemistry lcsh:QD1-999
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1. a) W. J. Geldenhuys, S. F. Malan, J. R. Bloomquist, A. P. Marchand, C. J. Van der Schyf, Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: a focus on pentacycloundecane derivatives, Med. Res. Rev. 25 (2005) 21-48, doi: http://dx.doi.org/10.1002/med.20013. b) C. J. Van der Schyf, W. J. Geldenhuys, Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?, Neurotherapeutics 6 (2009) 175-186, doi: http:// dx.doi.org/10.1016/j.nurt.2008.10.037. c) J. Joubert, W. J. Geldenhuys, C. J. Van der Schyf, D. W. Oliver, H. G. Kruger, T. Govender, S. F. Malan, Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs, ChemMedChem 7 (2012) 375-384, doi: http://dx.doi.org/10.1002/cmdc.201100559.
2. a) O. K. Onajole, P. Govender, P. D. van Helden, H. G. Kruger, G. E. Maguire, I. Wiid, T. Govender, Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates, Eur. J. Med. Chem. 45 (2010) 2075-2079, doi: http://dx.doi. org/10.1016/j.ejmech.2010.01.046. b) G. Lamoureux, G. Artavia, Use of the adamantane structure in medicinal chemistry, Curr. Med. Chem. 17 (2010) 2967-2978, doi: http:// dx.doi.org/10.2174/092986710792065027. [OpenAIRE]
3. a) L. Wanka, K. Iqbal, P. R. Schreiner, The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives, Chem. Rev. 113 (2013) 3516-3604, doi: http://dx.doi. org/10.1021/cr100264t. b) J. Liu, D. Obando, V. Liao, T. Lifa, R. Codd, The many faces of the adamantyl group in drug design, Eur. J. Med. Chem. 46 (2011) 1949-1963, doi: http:// dx.doi.org/10.1016/j.ejmech.2011.01.047. [OpenAIRE]
4. R. C. Fort Jr., Adamantane - The chemistry of diamond molecules, Marcel Dekker, Inc., New York, 1976.
5. C. F. Chew, A. Guy, P. C. Biggin, Distribution and dynamics of adamantanes in a lipid bilayer, Biophys. J. 95 (2008) 5627- 5636, doi: http://dx.doi.org/10.1529/biophysj.108.139477. [OpenAIRE]
6. T. Ishikawa, Superbases for organic synthesis: guanidines, amidines and phosphazenes and related organocatalysts, John Wiley & Sons, Ltd, Chichester, West Sussex, United Kingdom, 2009., doi: http://dx.doi.org/10.1002/9780470740859.
7. E. D. Raczyńska, M. K. Cyrański, M. Gutowski, J. Rak, J.-F. Gal, P.-C. Maria, M. Darowska, K. Duczmal, Consequences of proton transfer in guanidine, J. Phys. Org. Chem. 16 (2003) 91-106, doi: http://dx.doi.org/10.1002/poc.578.
8. D. Castagnolo, S. Schenone, M. Botta, Guanylated diamines, triamines, and polyamines: Chemistry and biological properties, Chem. Rev. 111 (2011) 5247-5300, doi: http://dx.doi. org/10.1021/cr100423x. [OpenAIRE]
9.C. L. Hannon, E. V. Anslyn, The guanidinium group: Its biological role and synthetic analogs, Bioorganic Chemistry Frontiers, vol. 3, Springer, Berlin, 1993., str. 193-255.
10. R. G. S. Berlinck, Natural guanidine derivatives, Nat. Prod. Rep. 16 (1999) 339-365, doi: http://dx.doi.org/10.1039/ a900338j.
- Ruđer Bošković Institute Croatia
Biological activity of different adamantane derivatives and their application has been described in various reviews. Similarly, many reviews deal with biological activity and application of guanidine compounds. However, up to now no review has been made concerning the guanidine derivatives of adamantane and other polycycles, compounds which incorporate both of these moieties in the same molecule. Therefore, a literature survey of polycyclic guanidine derivatives is here provided and their application as potential pharmacophores stressed.
Biološka aktivnost različitih adamantanskih derivata i njihova primjena opisane su u brojnim preglednim člancima. Isto tako, mnogi revijalni članci opisuju biološku aktivnost i primjenu gvanidinskih spojeva. Međutim do sada nije načinjen pregled koji bi se bavio gvanidinskim derivatima adamantana i drugih policikla, tj. spojevima koji sadrže obje navedene podjedinice u istoj molekuli. U ovom radu bit će stoga dan pregled policikličkih derivata gvanidina, i to s naglaskom na njihovu primjenu kao potencijalnih farmakofora.