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Kemija u Industriji
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Preparation of 3D Porous Scaffolds for Bone Tissue Engineering

Authors: Marica Ivanković; Leonard Bauer; Antonia Ressler; Anamarija Rogina; Maja Antunović; Hrvoje Ivanković;

Preparation of 3D Porous Scaffolds for Bone Tissue Engineering

Abstract

Bone tissue engineering (BTE) is a fast growing field focused on the development of bioactive 3D porous scaffolds as temporary extracellular matrixes that support cell attachment, proliferation and differentiation, and stimulate bone tissue formation in vivo. Over more than ten years, our group has been devoted to developing new biomaterials and methods to prepare 3D porous scaffolds for BTE applications. The potential of natural porous structures such as marine skeletons, composite materials, and hydrogels based on biodegradable polymers and bioresorbable hydroxyapatite ceramics have been studied. In this paper, an overview of our research and main achievements, published in international scientific publications, is provided. This work is licensed under a Creative Commons Attribution 4.0 International License.

Inženjerstvo koštanog tkiva brzorastuće je polje istraživanja usmjereno na razvoj bioaktivnih 3D poroznih nosača, kao privremenih izvanstaničnih matrica, koji podržavaju prianjanje, umnažanje i diferencijaciju stanica te potiču stvaranje koštanog tkiva in vivo. Više od deset godina istraživanja naše grupe posvećena su razvoju novih materijala i postupaka za pripravu 3D poroznih nosača za inženjerstvo koštanog tkiva. Kao mogući nosači istraživani su porozni skeleti morskih organizama te kompozitni materijali i hidrogelovi na temelju biorazgradljivih polimera i bioresorbirajuće hidroksiapatitne keramike. U ovom radu dan je prikaz naših istraživanja i glavnih postignuća, objavljenih u međunarodnim znanstvenim publikacijama. Ovo djelo je dano na korištenje pod licencom Creative Commons Imenovanje 4.0 međunarodna.

Country
Croatia
Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:Chemistry lcsh:QD1-999

Keywords

inženjerstvo koštanog tkiva, biorazgradljivi polimeri, hidrogelovi, 3D nosači, porozna struktura, inženjerstvo koštanog tkiva ; 3D nosači ; porozna struktura ; sipina kost ; hidroksiapatit ; biorazgradljivi polimeri ; hidrogelovi, bone tissue engineering; 3D scaffolds; porous structure; cuttlefish bone; hydroxyapatite; biodegradable polymers; hydrogels, sipina kost, hidroksiapatit, inženjerstvo koštanog tkiva; 3D nosači; porozna struktura; sipina kost; hidroksiapatit; biorazgradljivi polimeri; hidrogelovi

39 references, page 1 of 4

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1. F. J. O'Brien, Biomaterials & scaffolds for tissue engineering, Mater. Today 14 (2011) 88-90, doi: https://doi.org/10.1016/ S1369-7021(11)70058-X.

2. C. Liu, Z. Xia, J. T. Czernuszka, Design and development of three-dimensional scaffolds for tissue engineering, Chem. Eng. Res. Des. 85 (2007) 1051-1064, doi: https://doi. org/10.1205/cherd06196.

3. I. M. El-Sherbiny, M. H. Yacoub, Hydrogel scaffolds for tissue engineering: Progress and challenges, Glob. Cardiol. Sci. Pract. 2013 (2013) 316-342, doi: https://doi.org/10.5339/ gcsp.2013.38. [OpenAIRE]

4. L. Đudarić, S. Zoričić Cvek, O. Cvijanović, A. Fužinac-Smojver, T. Ćelić, D. Martinović, Osnove biologije koštanog tkiva, Med. Flum. 50 (2014) 21-38. [OpenAIRE]

5. V. Čadež, Nove metode priprave bioimplantata: značaj istraživanja biomineralne strukture morskih beskralješnjaka za razumijevanje procesa mineralizacije kralješnjaka, Med. Vjesn. 43 (2011) 91-101. [OpenAIRE]

6. T.-M. De Witte, L. E. Fratila-Apachitei, A. A. Zadpoor, N. A. Peppas, Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices, Regen. Biomater. 5 (2018) 197-211, doi: https://doi.org/10.1093/rb/rby013. [OpenAIRE]

7. M. H. Fathi, A. Hanifi, V. Mortazavi, Preparation and bioactivity evaluation of bone-like hydroxyapatite nanopowder, J. Mater. Process. Technol. 202 (2008) 536-542, doi: https:// doi.org/10.1016/j.jmatprotec.2007.10.004.

8. J. R. Woodard, A. J. Hilldore, S. K. Lan, C. J. Park, A. W. Morgan, J. A. C. Eurell, S. G. Clark, M. B. Wheeler, R. D. Jamison, A. J. Wagoner Johnson, The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity, Biomater. 28 (2007) 45-54, doi: https://doi. org/10.1016/j.biomaterials.2006.08.021.

9. H. Ivanković, G. Gallego Ferrer, E. Tkalčec, M. Ivanković, Preparation of highly porous hydroxyapatite ceramics from cuttlefish bone, Adv. Sci. Tech. 49 (2006) 142-147, doi: https://doi.org/10.4028/www.scientific.net/AST.49.142 .

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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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