RECENT ADVANCES IN DIAGNOSIS, MANAGEMENT AND PREVENTION OF RH IMMUNISATION

Other literature type Croatian OPEN
Matijević, Ratko ; Knežević, Mario (2009)
  • Publisher: Croatian Society of Gynaecology and Obstetrics, and Croatian Society of Perinatal Medicine of Croatian Medical Association
  • Journal: Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, volume 18, issue 2 (issn: 1330-0091)
  • Subject: Rh imunizacija; dijagnostika; dopler; fetalna anemija; intrauterina intravaskularna transfuzija; prevencija | Rh immunization; diagnosis; Doppler; fetal anemia; intrauterine intravascular transfusion; prevention

Rh immunization and hemolytic disease of the fetus and newborn (HDFN) are one of the most common causes of fetal anemia in pregnancy. Traditionally used amniocentesis and determination of OD 450 using Liley diagram is nowadays replaced by measurements of the peak systolic velocity of the blood flow in the middle fetal cerebral artery. Further advances are obtained in the treatment of HDFN where conservative treatment is completely replaced by intrauterine intravascular blood transfusion. As well as that, there is a marked improvement obtained by adapting the prophylactic protocol, with the most important, administration of anti D immunoglobulin to all Rh negative women. These three procedures resulted in reduction of perinatal mortality and morbidity related to HDFN.
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