Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

Other literature type English OPEN
Ribić, Rosana; Habjanec, Lidija; Vranešić, Branka; Frkanec, Ruža; Tomić, Srđanka;
  • Publisher: Croatian Chemical Society
  • Journal: Croatica Chemica Acta,volume 84,issue 2 (issn: 0011-1643, eissn: 1334-417X)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.5562/cca1827
  • Subject: O-mannopyranosides; adamantyltripeptides; peptidoglycan monomer; immunomodulation
    mesheuropmc: carbohydrates (lipids)

A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man- OCH2CH(CH3)CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory properties investigated in some preliminary tests in vivo. All newly synthe... View more