publication . Other literature type . 2009

The Effects of Long-Term Experimental Diabetes Mellitus Type I on Skeletal Muscle Regeneration Capacity

Jerković, Romana; Bosnar, Alan; Jurišić-Eržen, Dubravka; Ažman, Josip; Starčević-Klasan, Gordana; Peharec, Stanislav; Čoklo, Miran;
Open Access English
  • Published: 01 Jan 2009 Journal: Collegium antropologicum, volume 33, issue 4 (issn: 0350-6134, eissn: 1848-9486, Copyright policy)
  • Publisher: Croatian Anthropological Society
Abstract
Muscle fibers are dynamic structures capable of altering their phenotype under various pathological conditions. The aim of the present study was to investigate the influence of long-lasting diabetes mellitus on the process of muscle regeneration in the skeletal muscle. Wistar rats were made diabetic by a single intraperitoneal injection of streptozotocin (STZ). The regeneration process in the skeletal muscle was induced in slow (m. soleus, SOL) and fast (m. extensor digitorum longus, EDL) muscles by injection of local anesthetic (bupivacaine). Skeletal muscles were analyzed 10 days, 4 and 8 weeks after bupivacaine treatment. Diabetes mellitus has changed morphol...
Subjects
free text keywords: skeletal muscle; regeneration; type 1 diabetes mellitus; atrophy; rat
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