publication . Other literature type . Article . 2012

Interleukin-1 gene locus polymorphisms are associated with risk to breast cancer in Croatian population

Kaarvatn, M. H.; Eftedal, R. K.; Vrbanec, J.; Jotanovic, Z.; Etokebe, G. E.; Sanja Balen; Kulic, A.; Dembic, Z.;
Open Access English
  • Published: 01 Jan 2012 Journal: Periodicum biologorum, volume 114, issue 4 (issn: 0031-5362, eissn: 1849-0964, Copyright policy)
  • Publisher: Croatian Society of Natural Sciences
Abstract
Breast cancer has a complex genetic susceptibility. Innate and adaptive immunity can additionally increase the genetic risk to breast cancer development. We typed polymorphisms in the genes of the interleukin(IL)-1 and IL-17 proinflammatory cytokines in a case-control study in Caucasian population from Croatia. We compared the allelic and genotypic frequencies between patients (n=194), healthy women (n=188) and general population (n=531). The risk for breast cancer has been significantly different at both allelic and genotypic levels for two polymorphisms: the IL1B gene single nucleotide polymorphism (SNP) at -511 (G>A; rs16944) and the IL1 Receptor antagonist g...
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publication . Other literature type . Article . 2012

Interleukin-1 gene locus polymorphisms are associated with risk to breast cancer in Croatian population

Kaarvatn, M. H.; Eftedal, R. K.; Vrbanec, J.; Jotanovic, Z.; Etokebe, G. E.; Sanja Balen; Kulic, A.; Dembic, Z.;