publication . Article . Other literature type . 2011

Leishmania NAD+ metabolism

Jean-François Guichou; Ricardo Silvestre; C. Gérard; Anabela Cordeiro-da-Silva; Ali Ouaissi; Ali Ouaissi; Denis Sereno; Martial Seveno; Deborah Garcia; Elodie Gazanion; ...
Open Access
  • Published: 01 Sep 2011 Journal: Molecular Microbiology, volume 82, pages 21-38 (issn: 0950-382X, Copyright policy)
  • Publisher: Wiley
  • Country: France
Abstract
NAD(+) is a central cofactor that plays important roles in cellular metabolism and energy production in all living cells. Genomics-based reconstruction of NAD(+) metabolism revealed that Leishmania protozoan parasites are NAD(+) auxotrophs. Consequently, these parasites require assimilating NAD(+) precursors (nicotinamide, nicotinic acid, nicotinamide riboside) from their host environment to synthesize NAD(+) by a salvage pathway. Nicotinamidase is a key enzyme of this salvage pathway that catalyses conversion of nicotinamide (NAm) to nicotinic acid (Na), and that is absent in higher eukaryotes. We present here the biochemical and functional characterizations of...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Molecular Biology, Microbiology, Nicotinamide, chemistry.chemical_compound, chemistry, Nucleotide salvage, Biochemistry, Nicotinamide riboside, Leishmania infantum, biology.organism_classification, biology, Nicotinamidase, Enzyme, chemistry.chemical_classification, NAD+ kinase, Cofactor, biology.protein
Abstract
NAD(+) is a central cofactor that plays important roles in cellular metabolism and energy production in all living cells. Genomics-based reconstruction of NAD(+) metabolism revealed that Leishmania protozoan parasites are NAD(+) auxotrophs. Consequently, these parasites require assimilating NAD(+) precursors (nicotinamide, nicotinic acid, nicotinamide riboside) from their host environment to synthesize NAD(+) by a salvage pathway. Nicotinamidase is a key enzyme of this salvage pathway that catalyses conversion of nicotinamide (NAm) to nicotinic acid (Na), and that is absent in higher eukaryotes. We present here the biochemical and functional characterizations of...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Molecular Biology, Microbiology, Nicotinamide, chemistry.chemical_compound, chemistry, Nucleotide salvage, Biochemistry, Nicotinamide riboside, Leishmania infantum, biology.organism_classification, biology, Nicotinamidase, Enzyme, chemistry.chemical_classification, NAD+ kinase, Cofactor, biology.protein
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