Short synthesis and antimalarial activity of fagaronine

Other literature type OPEN
Rivaud, M.; Mendoza, A.; Sauvain, Michel; Valentin, A.; Jullian, Valérie;
  • Subject: Synthesis | In vivo experiment | Fagaronine | Benzo[c]phenanthridine | Malaria
    mesheuropmc: parasitic diseases

Herein, we report a new synthesis of fagaronine 1, inspired by the synthesis reported by Luo for nornitidine. The in vitro biological activity of fagaronine against malaria on several chloroquine-sensitive and resistant Plasmodium falciparum strains was confirmed, and t... View more
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