publication . Thesis . 2011

Advanced photonic methodologies for the 'in vitro' manipulation of cellular systems

McDougall, Craig;
Open Access English
  • Published: 01 Jan 2011
  • Publisher: University of St Andrews
  • Country: United Kingdom
Abstract
This thesis investigates the application of a variety of optical techniques for the manipulation of single cells and their local micro-environment. The methodologies developed provide enhanced control over a single cell under study affording exquisite spatial and temporal control over biological processes of interest. The work presented within the thesis can be split into three distinct categories. The first of these provides an investigation in light activated “caged” molecular probes. This work generated several new compounds which were then applied to providing control over processes involved in pain, mitochondrial intracellular signalling and memory processe...
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Subjects
free text keywords: QH585.5L37M3, Lasers in cytology, Photonics, Micrurgy, Molecular probes, Transfection
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