publication . Article . Other literature type . 2010

Cetuximab-induced aseptic meningitis

Ulrich, A; Weiler, S; Weller, M; Rordorf, T; Tarnutzer, A A;
Open Access
  • Published: 01 May 2010 Journal: Journal of Thoracic Oncology, volume 5, issue 5 (issn: 1556-0864, Copyright policy)
  • Publisher: Elsevier BV
  • Country: Switzerland
Abstract
Abstract We report a 67-year-old man with recurrent advanced oropharyngeal squamous cell carcinoma who developed aseptic meningitis, with first symptoms arising approximately 9 hours after the first administration of cetuximab, and review the literature to identify key signs and symptoms of this condition. Cetuximab is a monoclonal antibody targeting the epidermal growth factor receptor which has been rarely associated with aseptic meningitis. Besides the case description, a MEDLINE search was performed. In five patients identified in the literature and our patient, the leading signs and symptoms included headache, neck stiffness and high fever developing within...
Subjects
free text keywords: Clinic for Neurology, Clinic for Clinical Pharmacology and Toxicology, Clinic for Oncology and Hematology, 610 Medicine & health, Oncology, Pulmonary and Respiratory Medicine, Hematology, Aseptic meningitis, medicine.disease, medicine, General surgery, medicine.medical_specialty, Cetuximab, medicine.drug, Surgery, business.industry, business, Physiology (medical), Neurology, Clinical Neurology, General Medicine, Epidermal growth factor receptor, biology.protein, biology, Cerebrospinal fluid, Complication, Adverse drug reaction, Pleocytosis, Neck stiffness
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publication . Article . Other literature type . 2010

Cetuximab-induced aseptic meningitis

Ulrich, A; Weiler, S; Weller, M; Rordorf, T; Tarnutzer, A A;